Alpha-tocopheryl succinate, in contrast to alpha-tocopherol and alpha-tocopheryl acetate, inhibits prostaglandin E2 production in human lung epithelial cells
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منابع مشابه
RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria.
Previous studies have identified RRR-alpha-tocopheryl succinate (vitamin E succinate, VES) as a potential chemotherapeutic agent. VES induces human breast cancer cells to undergo apoptosis in a concentration- and time-dependent manner by restoring transforming growth factor beta (TGF-beta) and Fas (CD95) apoptotic signaling pathways, that contribute to the activation of c-Jun NH(2)-terminal kin...
متن کاملMetabolic effects of alpha-tocopheryl acetate. II. Influence of alpha-tocopheryl acetate on cholesterol and phospholipid synthesis in rat liver homogenates.
Gray and Loh (1) have shown previously that dietary ƒ¿-tocopheryl acetate (ƒ¿ TAc) brings about increases in phospholipids, total and free cholesterol in the plasma of healthy human subjects. It seemed probable that the dietary ƒ¿TAc affected the liver cell itself, the blood being merely a transport medium. This hypothesis was investigated, using rat liver homogenates from animals main tained f...
متن کاملALPHA -TOCOPHEROL IN CANCER
Serum alpha-tocopherol of98(62 male and 36 female) cancer patients and 30 (13 male and 17 female) control healthy subjects was investigated. The cancer patients showed a significantly low level of alpha-tocopherol as compared to control healthy subjects. Also, significantly higher levels of serum alpha-tocopherol were found in complete remission patients as compared to the partial response...
متن کاملAlpha-Tocopheryl Succinate Inhibits Autophagic Survival of Prostate Cancer Cells Induced by Vitamin K3 and Ascorbate to Trigger Cell Death
BACKGROUND The redox-silent vitamin E analog α-tocopheryl succinate (α-TOS) was found to synergistically cooperate with vitamin K3 (VK3) plus ascorbic acid (AA) in the induction of cancer cell-selective apoptosis via a caspase-independent pathway. Here we investigated the molecular mechanism(s) underlying cell death induced in prostate cancer cells by α-TOS, VK3 and AA, and the potential use of...
متن کاملBid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells.
The underlying mechanisms of alpha-tocopheryl succinate (alpha-TOS)-mediated apoptosis are not understood in detail, although the redox-silent vitamin E analog is a potent apoptogen and anti-cancer agent. Our previous studies showed the important role of Fas signaling in apoptosis induced by the mitocan. The objective of the present study was to investigate whether apoptosis triggered by alpha-...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2006
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgl073